Mt2

[`Eagle´]

Hi, hab eben ein Bericht über Melanotan One und Melanotan 2 gelesen, kennt das jemand?

Melanotan stimuliert die Melanin-Produktion in
den Melanozyten.
In der Folge erhöht sich der Gehalt an Melanin
in der Haut um bis zu 100 %, die Haut wird braun.
Der höhere Melaningehalt bietet zusätzlichen
Schutz vor schädlichen Auswirkungen der UV-
Strahlung.

[***Nakatomi***]

hab dieses gefunden. ist echt übel

My name is Robert, I'm 23 and I had been using melanotan II for over 1 year with great results. However, recently I got vision problems (with gradual onset) and thus went to see an ophthalmologist. I was diagnostized with a severe form of central serous retinopathy (CSR). Although CSR rarely leads to blindness, usually some vision impairment remains. There is no effective treatment for this condition.
She also found a rather big nevus (mole) on the choroid in my left eye which hasn't been there before (have had an eye exam in the past). This cannot be removed and have to be monitored for the rest of my life because it may lead to cancer at some point. She had no idea regarding the cause. Apart from being a bit myopic, my eyes were perfectly healthy before. I didn't tell her about Melanotan by the way.

Afterwards I did some research and found out that Central serous retinopathy is linked to therapeutic use of adrenocorticotrophic hormone (ACTH):

"ACTH has a melanotrophic part, melanocyte-stimulating hormone (MSH), that may affect RPE cells, which are melanin-pigmented cells of neuroectoderm origin, and alter their ionic pumping properties. This is supported by evidence in the literature for the effect of MSH on animal RPE cells, as well as on other secreting epithelia."

Melanotan and melanotan II are are both analogs of (alpha) MSH and thus sharing the same effects. Therefore it can be assumed that my condition is connected to the prolonged intake of melanotan II.

I then checked back with my doctor and was advised to stop taking Melanotan immediately.

I also made an appointment with the director of the dermatology department on our university (I'm a medical student myself) to get an expert opinion on Melanotan. He had heard of Melanotan before, but he would strongly discourage anyone from taking it especially for merely cosmetic purposes.
Though it may be beneficial to some people with certain skin diseases, it certainly bears great risks. He also didn't seem to be surprised about my case at all. Because the choroid (the underlying layer of the eye's retina) contains melanocytes, it will also be necessarily affected by Melanotan which in turn may effect the function of the retina. He also warned me about hormone and skin changes, which are probably not fully reversible even after being off of Melanotan for a very long time. There is a study that says MSH (again, Melanotan is just a synthetic copy of MSH) not only stimulates the melanocytes to produce melanin, but also cause proliferation of melanocytes:

"alpha-Melanocyte stimulating hormone (alpha-MSH) and ACTH increase the proliferation and melanogenesis of cultured human melanocytes."

This is quite contrary to an older study from 1986 which is cited on Clinuvel's website. Personally, I would not put much trust in studies published by Clinuvel. They are not obligated to release informations about dangers connected to Melanotan at this point. And I doubt they will voluntary discredit their only product.

Being a type I myself nobody can understand you better than I but there certainly are things in life that are more important than having a tanned skin. Don't put them at risk.

Actually, I curse the day when I first heard of Melanotan.

Zamir E (1997): "Central serous retinopathy associated with adrenocorticotrophic hormone therapy. A case report and a hypothesis". Hadassah University Hospital, Jerusalem, Israel

I Suzuki et al. (1996): "Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis" Department of Dermatology, University of Cincinnati, Ohio, USA
davon kann man nur abraten!

[Schnueffler]

davon kann man nur abraten!
Ist ein NICHT ZUGELASSENES MEDIKAMENT!
Und das nicht ohne Grund.
Die Nebenwirkungen sind noch in keinster Art und Weise erforscht.
Was man derzeit auf dem Schwarzmarkt oder irgendwelchen I-Net Apos bekommt, ist meißt verunreinigter Schrott oder Generika aus Indien/Pakistan/China, die irgendwelche Forschungspräparate kopieren, die noch in der Anfangsphase der Entwicklung stehen!
Du wirst braun werden und ne Menge an Fett verlieren, aber die Schäden werden dich spätestens in ein paar Jahren einholen!!!