Hi,
Ich hatte über die letzten Jahre des öfteren die "Stille Feiung" erwähnt, was im Grunde der berühmte "asymptomatischer Verlauf" ist. Grob gesagt bedeutet es, dass man so wenig Virenlast abbekommt, dass das eigene Immunsystem damit ohne größere Probleme fertig wird und es deshalb auch zu keinen Symptomen kommt.
Jetzt gibt es eine deutsche Studie (CoNAN Langzeit Kohorten Studie), die im Grunde diese stille Feiung in Form von "asymptomatischen Infektionen" erwähnt und hier eine robuste T-Zell Immunität festgestellt hat:
https://www.medrxiv.org/content/10.1....05.22277237v1Zitat:
Abstract
Objectives: Understanding persistent cellular and humoral immune responses to SARS-CoV-2 will be of major importance to terminate the ongoing pandemic. Here we assessed long-term immunity in individuals with mild COVID-19 up to one year after a localized SARS-CoV-2 outbreak. Methods: CoNAN was a longitudinal population-based cohort study performed 1.5 months, 6 months and 12 months after a SARS-CoV-2 outbreak in a rural German community. We performed a time series of five different IgG immunoassays assessing SARS-CoV-2 antibody responses on serum samples from individuals that had been tested positive after a SARS-CoV-2 outbreak as well as in control individuals who had a negative PCR result. These analyses were complemented with the determination of spike-antigen specific TH cell responses in the same individuals. Results: All infected participants presented as asymptomatic or mild cases. Participants initially tested positive for SARS-CoV-2 infection either with PCR, antibody testing, or both had a rapid initial decline in the serum antibody levels in all serological test but showed a persisting and robust TH cell immunity as assessed by the detection of SARS-CoV-2 specificity of TH cells for up to one year after infection. Conclusion: Our data support the notion of a robust T cell immunity in mild and asymptomatic cases of SARS-CoV-2 up to one year after infection. We show that antibody titers decline over one year, but considering several test results, complete seroconversion is rare. Trial Registration: German Clinical Trials Register DRKS00022416.
Interessant ist auch, dass man hier ebenfalls festgestellt hat, dass die Antikörperzahl sich über dieses eine Jahr verringert hat, wenn auch nie vollständig verschwunden ist.
Gruß
Alef